Role of COMT inhibitors and dopamine agonists in the treatment of motor fluctuations
Identifieur interne : 003742 ( Main/Exploration ); précédent : 003741; suivant : 003743Role of COMT inhibitors and dopamine agonists in the treatment of motor fluctuations
Auteurs : Katherine L. Widnell [États-Unis] ; Cynthia Comella [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Apomorphine (pharmacology), Apomorphine (therapeutic use), Benzophenones (pharmacology), Benzophenones (therapeutic use), COMT inhibition, Catechol O-Methyltransferase Inhibitors, Catechols (pharmacology), Catechols (therapeutic use), Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Dopamine agonist, Ergolines (pharmacology), Ergolines (therapeutic use), Fluctuations, Human, Humans, Levodopa, Levodopa (pharmacology), Levodopa (therapeutic use), Movement Disorders (drug therapy), Movement Disorders (etiology), Nervous system diseases, Nitriles, Nitrophenols (pharmacology), Nitrophenols (therapeutic use), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Parkinson's disease, Prevention, Toxicity, Treatment, dopamine agonist, levodopa, motor fluctuations.
- MESH :
- chemical , pharmacology : Apomorphine, Benzophenones, Catechols, Dopamine Agonists, Ergolines, Levodopa, Nitrophenols.
- chemical , therapeutic use : Apomorphine, Benzophenones, Catechols, Dopamine Agonists, Ergolines, Levodopa, Nitrophenols.
- chemical : Catechol O-Methyltransferase Inhibitors, Nitriles.
- complications : Parkinson Disease.
- drug therapy : Movement Disorders, Parkinson Disease.
- etiology : Movement Disorders.
- Humans.
Abstract
Although levodopa remains the most effective drug for the symptomatic treatment of Parkinson's disease (PD), there are significant limitations to its chronic use. Growing preclinical and clinical evidence suggests that the severity of motor fluctuations is influenced both by PD severity and pulsatile stimulation of striatal dopamine receptors. Current management of motor fluctuations is based primarily on strategies to prolong the effects of dopaminergic stimulation. This prolongation is accomplished either through the use of long‐acting dopaminergic drugs or prolonging of the effects of levodopa. During the past decade, the armamentarium of dopamine agonists increased and agents that prolong the plasma half‐life of levodopa became available. Furthermore, recent clinical trials provide evidence‐based approaches to improve the management of motor fluctuations in patients with advanced and early PD. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20461
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-05">2005-05</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">S11</biblScope><biblScope unit="supplement">11</biblScope><biblScope unit="page" from="S30">S30</biblScope><biblScope unit="page" to="S37">S37</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">0F2A6E5F15C1C654BE72E1E19498EEAEABCF3607</idno><idno type="DOI">10.1002/mds.20461</idno><idno type="ArticleID">MDS20461</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apomorphine (pharmacology)</term><term>Apomorphine (therapeutic use)</term><term>Benzophenones (pharmacology)</term><term>Benzophenones (therapeutic use)</term><term>COMT inhibition</term><term>Catechol O-Methyltransferase Inhibitors</term><term>Catechols (pharmacology)</term><term>Catechols (therapeutic use)</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Dopamine agonist</term><term>Ergolines (pharmacology)</term><term>Ergolines (therapeutic use)</term><term>Fluctuations</term><term>Human</term><term>Humans</term><term>Levodopa</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Movement Disorders (drug therapy)</term><term>Movement Disorders (etiology)</term><term>Nervous system diseases</term><term>Nitriles</term><term>Nitrophenols (pharmacology)</term><term>Nitrophenols (therapeutic use)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prevention</term><term>Toxicity</term><term>Treatment</term><term>dopamine agonist</term><term>levodopa</term><term>motor fluctuations</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term><term>Benzophenones</term><term>Catechols</term><term>Dopamine Agonists</term><term>Ergolines</term><term>Levodopa</term><term>Nitrophenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Apomorphine</term><term>Benzophenones</term><term>Catechols</term><term>Dopamine Agonists</term><term>Ergolines</term><term>Levodopa</term><term>Nitrophenols</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Catechol O-Methyltransferase Inhibitors</term><term>Nitriles</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Movement Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Fluctuation</term><term>Homme</term><term>Lévodopa</term><term>Parkinson maladie</term><term>Prévention</term><term>Stimulant dopaminergique</term><term>Système nerveux pathologie</term><term>Toxicité</term><term>Traitement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although levodopa remains the most effective drug for the symptomatic treatment of Parkinson's disease (PD), there are significant limitations to its chronic use. Growing preclinical and clinical evidence suggests that the severity of motor fluctuations is influenced both by PD severity and pulsatile stimulation of striatal dopamine receptors. Current management of motor fluctuations is based primarily on strategies to prolong the effects of dopaminergic stimulation. This prolongation is accomplished either through the use of long‐acting dopaminergic drugs or prolonging of the effects of levodopa. During the past decade, the armamentarium of dopamine agonists increased and agents that prolong the plasma half‐life of levodopa became available. 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